Chromatin Remodeling: Nucleosomes Bulging at the Seams

نویسندگان

چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Chromatin Remodeling: Nucleosomes Bulging at the Seams

ATP-dependent chromatin remodeling enzymes, such as SWI/SNF, hydrolyze thousands of ATPs to regulate gene expression on chromatin fibers. Recent mechanistic studies suggest that these enzymes generate localized changes in DNA topology that drive formation of multiple, remodeled nucleosomal states.

متن کامل

Chromatin: Packaging without Nucleosomes

Dinoflagellates are unique among eukaryotes in their unusual 'dinokaryons' - nuclei that lack bulk histones. A new study finds that acquisition of a novel dinoflagellate chromatin protein was an early step in the transition to a nucleus lacking detectable nucleosomes.

متن کامل

Chromatin: Pushing nucleosomes around

In a eukaryotic cell, genomic DNA does not exist in a free state, but is intricately complexed with chromosomal proteins, particularly histones. The basic chromatin fibre consists of an array of nucleosomes, each packaging around 200 base pairs (bp) of DNA; 146 bp is wound around a core of eight histone molecules (two each of H2A, H2B, H3 and H4), with the remaining DNA forming a linker to the ...

متن کامل

The RSC chromatin remodeling enzyme plays a unique role in directing the accurate positioning of nucleosomes

Thank you for submitting your manuscript for consideration at The EMBO Journal. I apologise that it has taken so long to evaluate your manuscript, but I understand that my colleague forwarded you the reports while I was away. Overall the three referees that evaluated your study find it to be interesting, however, there are a number of concerns and issues that need to be addressed. One of the ma...

متن کامل

Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes

The yeast Chd1 protein acts to position nucleosomes across genomes. Here, we model the structure of the Chd1 protein in solution and when bound to nucleosomes. In the apo state, the DNA-binding domain contacts the edge of the nucleosome while in the presence of the non-hydrolyzable ATP analog, ADP-beryllium fluoride, we observe additional interactions between the ATPase domain and the adjacent ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Current Biology

سال: 2002

ISSN: 0960-9822

DOI: 10.1016/s0960-9822(02)00782-0